Experts from all areas of academic and medical research in hematology, oncology, cardiology, and pathology, take readers from the bench research through the role of platelets in disease, to new therapeutic approaches. Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 125 world experts from 14 countries. This award-winning reference provides clear presentations by basic scientists of the cellular, molecular, and genetic mechanisms of platelets and the subsequent pathophysiological processes such as thrombosis, hemorrhage, inflammation, and cancer. It also provides clear presentations by hematologists, oncologists, cardiologists, pathologists, and other clinicians on how antiplatelet therapy, gene therapy, and platelet transfusion can lead to new therapeutic approaches to diagnose and treat thrombosis and other cardiovascular diseases. Since the publication of the third edition, there continues to be a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. This Fourth Edition of Platelets will continue to draw all this information into a single, comprehensive and authoritative resource. Presents a comprehensive, translational source for all aspects of platelet biology, pathophysiology, and clinical manifestations in one reference workContains new chapters on topics such as the regulators of GPVI signaling, in vivo thrombosis evaluations, pharmaco genomics of platelets, interplay between anti-platelets and anti-coagulants in clinical practice, and redox regulation of platelet functionSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of plateletsProvides a full color reference with 250 illustrations and over 12,000 references