Name: Biochemistry and Genetics of Recq-Helicases (en Inglés)
Price: 502.54 PEN
Availability: InStock
Author: Lombard, David B.
ISBN: 9781461355373

portada Biochemistry and Genetics of Recq-Helicases (en Inglés)

Formato

Libro Físico

Autor

David B. Lombard

Editorial

Springer

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

23.4 x 15.6 x 0.6 cm

Peso

0.17 kg.

ISBN13

9781461355373

Categorías

Ciencias básicas de la medicina preclínica
Genética (no médica)
Bioquímica

Biochemistry and Genetics of Recq-Helicases (en Inglés)

David B. Lombard (Autor) · Springer · Tapa Blanda

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S/ 502,54

S/ 1.005,07

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Biochemistry and Genetics of Recq-Helicases (en Inglés)"

Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.