Name: Synthesis and Biological Evaluation of Mast Cell Stabilizers (en Inglés)
Price: 220.21 PEN
Availability: InStock
Author: Singh, Jatinder ; Singh, Nirmal ; Singh, Dhandeep
ISBN: 9786202673440

portada Synthesis and Biological Evaluation of Mast Cell Stabilizers (en Inglés)

Synthesis and Biological Evaluation of Mast Cell Stabilizers (en Inglés)

Formato

Libro Físico

Autor

Nirmal Singh

Jatinder Singh

Dhandeep Singh

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

108

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.7 cm

Peso

0.17 kg.

ISBN13

9786202673440

Categorías

Farmacología

Synthesis and Biological Evaluation of Mast Cell Stabilizers (en Inglés)

Nirmal Singh (Autor) · Jatinder Singh (Autor) · Dhandeep Singh (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Synthesis and Biological Evaluation of Mast Cell Stabilizers (en Inglés)"

The role of mast cells can be protective or harmful: depending upon the physiological/pathological condition in which they get activated. The latter role is due to mast cell degranulation and the release of an array of incendiary mediators. Mast cells have a well-established role in diseases like allergy, eczema, anaphylactic shock, mastocytosis, and other miscellaneous mast cell disorders. The derivatives of spiro-β-carboline were evaluated for mast cell stabilization activity by compound 48/80 induced degranulation histamine release assay. The mast cell stabilization of 2′-Heptyl-2′,3′,4′,9′-tetrahydrospiro[cyclohexane-1,1′-pyrido[3,4-b]indole]-3′-carboxylic acid (IC50 = 0.389 0.015 μM) and 2′-Benzoyl 2′,3′,4′,9′-tetrahydrospiro[cyclohexane-1,1′-pyrido[3,4-b]indole]-3′-carboxylic acid (IC50 = 00.469 0.032 μM) compounds were to be of similar potency as that of standard drug sodium cromoglycate (IC50 =0.489 0.003μM).