Name: Drug Transporters in Drug Disposition, Effects and Toxicity (en Inglés)
Price: 613.92 PEN
Availability: InStock
Author: Liu, Xiaodong ; Pan, Guoyu
ISBN: 9789811376467

portada Drug Transporters in Drug Disposition, Effects and Toxicity (en Inglés)

Drug Transporters in Drug Disposition, Effects and Toxicity (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

Liu, Xiaodong ; Pan, Guoyu

Idioma

Inglés

N° páginas

580

Encuadernación

Tapa Dura

ISBN13

9789811376467

Categorías

Farmacología
Farmacia/prescripción/dispensación
Bioquímica

Drug Transporters in Drug Disposition, Effects and Toxicity (en Inglés)

Liu, Xiaodong ; Pan, Guoyu (Autor) · Springer · Tapa Dura

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Reseña del libro "Drug Transporters in Drug Disposition, Effects and Toxicity (en Inglés)"

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presentsa number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.