This book presents OpenEDR4C, an innovative platform powered by AI and 5.0 technologies to develop complex thinking skills. Known as Education 5.0, it fosters scientific, technological, and social entrepreneurship through active learning in real-world contexts. Designed for students, educators, and decision-makers, it connects education, innovation, and open science, promoting solutions to priority challenges. By enabling lifelong learning and global collaboration, OpenEDR4C inspires innovation and prepares users to navigate complex systems for a better future.