Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles. Application to drug delivery system (en Inglés) - Huilin Ye;Zhiqiang Shen;Ying Li

Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. Current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles, adhesion on the endothelium wall, and subsequent internalization into diseased cells. To study the transport and adhesion of particles in vasculature, the authors of this book have made great effort to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This text discusses the recent achievements from the establishment of fundamental physical problems to the development of the multiscale model and, finally, large-scale simulations for understanding the transport of particle-based drug carriers in blood flow.