Name: Structural Study of Heterogeneous Biological Samples by Cryoelectron Microscopy and Image Processing (en Inglés)
Price: 98.31 PEN
Availability: InStock
Author: Ignatiou, A. ; Clare, D. K. ; Orlova, E. V.
ISBN: 9781545497548

portada Structural Study of Heterogeneous Biological Samples by Cryoelectron Microscopy and Image Processing (en Inglés)

Structural Study of Heterogeneous Biological Samples by Cryoelectron Microscopy and Image Processing (en Inglés)

Formato

Libro Físico

Autor

Editorial

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

27.9 x 21.6 x 0.2 cm

Peso

0.12 kg.

ISBN13

9781545497548

Categorías

Investigación médica

Structural Study of Heterogeneous Biological Samples by Cryoelectron Microscopy and Image Processing (en Inglés)

A. Ignatiou (Autor) · D. K. Clare (Autor) · E. V. Orlova (Autor) · Createspace · Tapa Blanda

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Reseña del libro "Structural Study of Heterogeneous Biological Samples by Cryoelectron Microscopy and Image Processing (en Inglés)"

In living organisms, biological macromolecules are intrinsically flexible and naturally exist in multiple conformations. Modern electron microscopy, especially at liquid nitrogen temperatures (cryo-EM), is able to visualise biocomplexes in nearly native conditions and in multiple conformational states. The advances made during the last decade in electronic technology and software development have led to the revelation of structural variations in complexes and also improved the resolution of EM structures. Nowadays, structural studies based on single particle analysis (SPA) suggests several approaches for the separation of different conformational states and therefore disclosure of the mechanisms for functioning of complexes. The task of resolving different states requires the examination of large datasets, sophisticated programs, and significant computing power. Some methods are based on analysis of two-dimensional images, while others are based on three-dimensional studies. In this review, we describe the basic principles implemented in the various techniques that are currently used in the analysis of structural conformations and provide some examples of successful applications of these methods in structural studies of biologically significant complexes.