Name: Syntheses & Applications of Steroid-Amino Acid Conjugates & Complexes (en Inglés)
SKU: 57300245
Price: 410.79 PEN
Availability: InStock
Author: Pandya, Keyur
ISBN: 9786139845354

portada Syntheses & Applications of Steroid-Amino Acid Conjugates & Complexes (en Inglés)

Syntheses & Applications of Steroid-Amino Acid Conjugates & Complexes (en Inglés)

Formato

Libro Físico

Autor

Keyur Pandya

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

280

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x1.6 cm

Peso

0.41 kg.

ISBN13

9786139845354

Categorías

Química

Syntheses & Applications of Steroid-Amino Acid Conjugates & Complexes (en Inglés)

Keyur Pandya (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Syntheses & Applications of Steroid-Amino Acid Conjugates & Complexes (en Inglés)"

Sesquiterpenoid- and steroid-amino acid conjugates demonstrate a broad array of interesting biological properties, as the different segments of the conjugate function collectively to regulate conformation, recognition, transport and solubility. The current project involved developing a facile methodology to synthesize metabolically stable facially amphiphilic conjugates by appending either amino acids (chapter 2) or cationic metal ligand-amino acid complexes (chapter 3) as hydrophilic segments on steroid progesterone and sesquiterpene amorpha-4,11-diene scaffolds. Aminosteroids and C-11 substituted steroids have attracted long lasting interest due to their diverse pharmacological properties. As the stereoselective C- 11β functionalization of a steroid imposes severe steric hindrance due to the C-18 and C-19 angular methyl groups, access to 11β-aminoprogesterone is a challenge. Chapter 2 describes stereoselective syntheses of a new family of aminosteroids: 11β-aminoprogesterone (11 -NH2-Pro) (76) and its derivatives, including its glycine 77 and L-/D- alanine- 78/79 based conjugates, by nucleophilic substitution or reductive amination.