Name: Apoptosis in Aspergillus fumigatus (en Inglés)
Price: 198.59 PEN
Availability: InStock
Author: Silva Da Trindade, Natália ; Rezende Morais, Enyara ; Dias Santos Júnior, Célio
ISBN: 9786202092562

portada Apoptosis in Aspergillus fumigatus (en Inglés)

Formato

Libro Físico

Autor

Natália Silva Da Trindade

Enyara Rezende Morais

Célio Dias Santos Júnior

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.3 cm

Peso

0.10 kg.

ISBN13

9786202092562

Categorías

Microbiología (no médica)

Apoptosis in Aspergillus fumigatus (en Inglés)

Natália Silva Da Trindade (Autor) · Enyara Rezende Morais (Autor) · Célio Dias Santos Júnior (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

Libro Nuevo

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S/ 397,18

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Apoptosis in Aspergillus fumigatus (en Inglés)"

Aspergillus fumigatus is a highly pathogenic fungus for immunocompromised patients and invasive aspergillosis exhibits mortality rates around 50-80%. Thus, the apoptosis pathway in this fungus may be an important target for the development of new drugs. From a data bank, we analyzed five different proteins (Bax, Bir, Nma111, Pca1, and Rad9) belonging to the apoptosis pathway in the genome of Aspergillus fumigatus. Phylogenetic trees, splits graphs, recombination analyses, and assessment of selection strength from codon to codon were developed to understand the evolution and the function of these proteins in the fungus. Our results suggest a conservation of these proteins in the Aspergillaceae family, as well as a low rate of gene recombination with a putative preservation of the function. We thus propose that the apoptosis pathway in Aspergillus fumigatus is started with the Rad9 protein followed by the activation of Bax and Pca1 proteins. Also, Nma111 cleaves the Bir protein resulting in the consequent activation of the Bax protein. Further studies are necessary to better understand the apoptosis process in Aspergillus fum