Name: Diabetes Mellitus: A Risk Factor for Alzheimer's Disease (en Inglés)
Price: 592.84 PEN
Availability: InStock
Author: Nakabeppu, Yusaku ; Ninomiya, Toshiharu
ISBN: 9789811335396

portada Diabetes Mellitus: A Risk Factor for Alzheimer's Disease (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

Nakabeppu, Yusaku ; Ninomiya, Toshiharu

Idioma

Inglés

N° páginas

248

Encuadernación

Tapa Dura

Dimensiones

16.5 x 23.6 x 1.8 cm

Peso

0.64 kg.

ISBN13

9789811335396

Categorías

El metabolismo
Endocrinología
Neurología y neurofisiología clínicas
Neurociencias

Diabetes Mellitus: A Risk Factor for Alzheimer's Disease (en Inglés)

Nakabeppu, Yusaku ; Ninomiya, Toshiharu (Autor) · Springer · Tapa Dura

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Reseña del libro "Diabetes Mellitus: A Risk Factor for Alzheimer's Disease (en Inglés)"

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer's disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.