Name: The Brichos Domain: Its Proproteins and Functions (Springerbriefs in Molecular Science) (en Inglés)
Price: 267.66 PEN
Availability: InStock
Author: Jenny Presto; Jan Johansson
ISBN: 9783319165639

portada The Brichos Domain: Its Proproteins and Functions (Springerbriefs in Molecular Science) (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

Jenny Presto; Jan Johansson

Año

2015

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

ISBN13

9783319165639

N° edición

2015

Categorías

Bioquímica

The Brichos Domain: Its Proproteins and Functions (Springerbriefs in Molecular Science) (en Inglés)

Jenny Presto; Jan Johansson (Autor) · Springer · Tapa Blanda

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Reseña del libro "The Brichos Domain: Its Proproteins and Functions (Springerbriefs in Molecular Science) (en Inglés)"

This Brief summarizes the current research on the novel BRICHOS domain, which is a chaperone domain found in a variety of proteins and is shown to exhibit anti-amyloidogenic chaperone-like functions. The BRICHOS domain is defined from sequence similarities, lacks established physiological function(s) and is found about 10 distantly related pro-protein families, several of which are associated with human disease. In this work, the authors review the mechanism by which BRICHOS inhibits Ass aggregation and examine recent results from in vivo experiments where BRICHOS inhibits Ass aggregation and toxicity in Drosophila melanogaster. BRICHOS is one of nature's (more specific) ways to protect against fibril formation, and exploring the potential of using the BRICHOS domain in the fight against Alzeimer's Disease and other amyloid diseases seems highly relevant. This brief is useful for newcomers to this field or researchers in related fields wishing to gain a quick overview of the latest findings.